Genetic associations between miR‑200bT>C and miR‑495A>C polymorphisms and hypertension susceptibility.

ABSTRACT: Although microRNA (miRNA)-mediated functions and gene expression regulation are involved in the susceptibility to vascular diseases, the potential effect of miRNA polymorphisms on the susceptibility of patients to hypertension (HTN) remains to be sufficiently elucidated. Therefore, the present study aimed to identify the potential association between miRNA (miR)-200bT>C (rs7549819) and miR-495A>C (rs2281611) polymorphisms, which may be implicated in stroke and vascular pathogenesis, and the susceptibility to HTN and relevant risk factors in a Korean cohort recruited from Jeju National University Hospital (Jeju, South Korea). Using an analysis of PCR-restriction fragment length polymorphism, genotype analysis was conducted to assess the frequency of miR-200bT>C and miR-495A>C gene polymorph

SUBMITTER: Choi Y 

PROVIDER: S-EPMC10267559 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature