Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity.

ABSTRACT:

Objective

Obesity is a complex disorder and is linked to chronic diseases such as type 2 diabetes. Major intrinsically disordered NOTCH2-associated receptor2 (MINAR2) is an understudied protein with an unknown role in obesity and metabolism. The purpose of this study was to determine the impact of Minar2 on adipose tissues and obesity.

Method

We generated Minar2 knockout (KO) mice and used various molecular, proteomic, biochemical, histopathology, and cell culture studies to determine the pathophysiological role of Minar2 in adipocytes.

Results

We demonstrated that the inactivation of Minar2 results in increased body fat with hypertrophic adipocytes. Minar2 KO mice on a high-fat diet develop obesity and impaired glucose tolerance and metabolism. Mechanistically, Minar

SUBMITTER: Lotfollahzadeh S 

PROVIDER: S-EPMC10267597 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature