Mechanisms regulating the properties of inhibition-based gamma oscillations in primate prefrontal and parietal cortices.

ABSTRACT: In primates, the dorsolateral prefrontal (DLPFC) and posterior parietal (PPC) cortices are key nodes in the working memory network. The working memory-related gamma oscillations induced in these areas, predominantly in layer 3, exhibit higher frequency in DLPFC. Although these regional differences in oscillation frequency are likely essential for information transfer between DLPFC and PPC, the mechanisms underlying these differences remain poorly understood. We investigated, in rhesus monkey, the DLPFC and PPC layer 3 pyramidal neuron (L3PN) properties that might regulate oscillation frequency and assessed the effects of these properties simulating oscillations in computational models. We found that GABAAR-mediated synaptic inhibition synchronizes L3PNs in both areas, but analysis of GABAA

SUBMITTER: Gonzalez-Burgos G 

PROVIDER: S-EPMC10267634 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature