Ontology highlight
ABSTRACT:
SUBMITTER: Okada M
PROVIDER: S-EPMC10267689 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Okada Morihiro M Takano Tomomi T Ikegawa Yuko Y Ciesielski Hanna H Nishida Hiroshi H Yoo Sa Kan SK
The EMBO journal 20230504 12
Cancer exerts pleiotropic, systemic effects on organisms, leading to health deterioration and eventually to organismal death. How cancer induces systemic effects on remote organs and the organism itself still remains elusive. Here we describe a role for NetrinB (NetB), a protein with a particularly well-characterized role as a tissue-level axon guidance cue, in mediating oncogenic stress-induced organismal, metabolic reprogramming as a systemic humoral factor. In Drosophila, Ras-induced dysplast ...[more]