A causal relationship between irritability and cardiovascular diseases: a Mendelian randomization study.

ABSTRACT:

Background

Observational studies have suggested that irritability is associated with a higher risk of cardiovascular disease (CVD). However, the potential causal association is not clear. Therefore, we used Mendelian randomization (MR) analysis to assess the causal association of irritability with CVD risk.

Methods

A two-sample MR analysis was performed to confirm the causal association of irritability with the risk of several common CVDs. The exposure data were derived from the UK biobank involving 90,282 cases and 232,386 controls, and outcome data were collected from the published genome-wide association studies (GWAS) and FinnGen database. Inverse-variance weighted (IVW), MR-Egger, and weighted median methods were performed to assess the causal association. Furthermore,

SUBMITTER: Cai D 

PROVIDER: S-EPMC10267866 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature