Generic Liquid Membranes for Electromembrane Extraction of Bases with Low or Moderate Hydrophilicity.

ABSTRACT: For the first time, this paper introduces the idea of generic extraction conditions in electromembrane extraction (EME), where the selection of the liquid membrane is based on the charge (z) and hydrophobicity (log P) of the analyte. A broad range of organic solvents were tested as liquid membranes, and 90 basic pharmaceuticals were used as model analytes (-4.2 < log P < 8.1). 2-Nitrophenyl octyl ether (NPOE) was confirmed as a highly efficient liquid membrane for mono- and dibases (+1.0 ≤ z ≤ +2.0) of low polarity in the log P range of 2.2-6.4. This log P range was set as the extraction window (operational range) of NPOE. NPOE provided very high operational stability. At 50 V, the current was at a 1 μA level, and gas formation and drifting pH due

SUBMITTER: Zhou C 

PROVIDER: S-EPMC10267886 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature