Changes in targeted metabolomics in lung tissue of chronic obstructive pulmonary disease

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is a common chronic lung disease and its incidence is steadily increasing. COPD patients and mouse models of COPD share some similarities in lung pathology and physiology. We performed this study to explore the potential metabolic pathways involved in the pathogenesis of COPD and to discover the COPD-associated biomarkers. Furthermore, we aimed to examine how much the mouse model of COPD was similar and different to human COPD in terms of the altered metabolites and pathways.

Methods

Twenty human lung tissue samples (ten COPD and ten controls) and twelve mice lung tissue samples (six COPD and six controls) were analyzed by targeted HM350 metabolomics, and multivariate and pathway analysis were performed by Kyoto Ency

SUBMITTER: Feng Y 

PROVIDER: S-EPMC10267913 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature