Oral rifampicin interferes with urine dipstick tests for patients with pulmonary tuberculosis.

ABSTRACT:

Background

Rifampicin (RMP) and its major metabolite, desacetyl rifampicin (dRMP), can interfere with urine dipstick tests (UDTs) in patients with tuberculosis (TB) who receive oral RMP. This study sought to examine the effects of RMP and dRMP on UDTs using 2 different urine dipsticks (i.e., Arkray's Aution Sticks 10EA and GIMA's Combi-Screen 11SYS Plus sticks).

Methods

Urine colorimetry was applied to measure RMP concentrations and determine the range of total RMP concentration in the urine within 2-6 and 12-24 h of oral administration of RMP. In vitro interference assays and confirmatory tests were performed to evaluate the effects of RMP and dRMP on the analytes.

Results

The total RMP concentration in the urine of the 40 TB patients analyzed as urine sample was 88-

SUBMITTER: Wang F 

PROVIDER: S-EPMC10267930 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature