Analysis of real-world data to investigate evolving treatment sequencing patterns in advanced non-small cell lung cancers and their impact on survival.

ABSTRACT:

Background

Although optimal sequencing of systemic therapy in cancer care is critical to achieving maximal clinical benefit, there is a lack of analysis of treatment sequencing in advanced non-small cell lung cancer (aNSCLC) in real-world settings.

Methods

A retrospective cohort study of 13,340 lung cancer patients within the Mount Sinai Health System (MSHS) was performed. Systemic therapy data of aNSCLC in 2,106 patients was the starting point in our analysis to investigate how treatment sequencing has evolved, the impact of sequencing patterns on clinical outcomes, and the effectiveness of 2^nd line chemotherapy after patients progressed on immune checkpoint inhibitor (ICI)-based therapy as the 1^st line of therapy (LOT).

Results

There is a signi

SUBMITTER: Liu Z 

PROVIDER: S-EPMC10267939 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature