Treatment of rheumatoid arthritis-associated interstitial lung disease in a multi-center registry cohort.

ABSTRACT:

Background

Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is challenging to manage, with a paucity of robust data to guide treatment. Our aim was to characterize the pharmacologic treatment of RA-ILD utilizing a retrospective design in a national multi-center prospective cohort, and to identify associations between treatment and change in lung function and survival.

Methods

Patients with RA-ILD and a radiological pattern of non-specific interstitial pneumonia (NSIP) or usual interstitial pneumonia (UIP) were included. Unadjusted and adjusted linear mixed models and Cox proportional hazards models were used to compare lung function change and risk of death or lung transplant by radiologic patterns and treatment.

Results

Of 161 patients with RA-ILD,

SUBMITTER: Marcoux V 

PROVIDER: S-EPMC10267945 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature