PCK2 inhibits lung adenocarcinoma tumor cell immune escape through oxidative stress-induced senescence as a potential therapeutic target.

ABSTRACT:

Background

Our research aimed to better understand how phosphoenolpyruvate carboxykinase 2 (PCK2) is linked to survival outcomes in lung cancer patients.

Methods

We confirmed PCK2 expression and its association with the outcome of lung cancer patients using The Cancer Genome Atlas (TCGA) database. PCK2 and immune cell connections were investigated using data from the Tumor IMmune Estimation Resource (TIMER) and TCGA repositories. We used the CancerSEA database to examine the links between PCK2 expression and the efficiency of lung adenocarcinomas, and a T-distributed Stochastic Neighbor Embedding (T-SNE) map was constructed to show the expression profile of PCK2 in single cells in TCGA lung adenocarcinoma samples. The potential mechanism of

SUBMITTER: Tang M 

PROVIDER: S-EPMC10267946 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature