Postnatal intestinal mucosa and gut microbial composition develop hand in hand: A mouse study.

ABSTRACT:

Background

During the early postnatal life, gut microbiota development experiences dynamic changes in their structural and functional composition. The postnatal period is the critical window to develop a host defense mechanism. The maturation of intestinal mucosal barrier integrity is one of the essential defense mechanisms to prevent the entry of pathogens. However, the co-development of intestinal microbial colonization, formation of barrier integrity, and intestinal epithelial cell layer is not entirely understood.

Methods

We studied the gut microbial composition and diversity using 16S rRNA marker gene-based sequencing in mice to understand postnatal age-dependent association kinetics between gut microbial and intestinal development. Next, we assessed the intestinal deve

SUBMITTER: Pandey U 

PROVIDER: S-EPMC10267966 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature