Accessing Bioactive Hydrazones by the Hydrohydrazination of Terminal Alkynes Catalyzed by Gold(I) Acyclic Aminooxy Carbene Complexes and Their Gold(I) Arylthiolato and Gold(III) Tribromo Derivatives: A Combined Experimental and Computational Study.

ABSTRACT: Hydrohydrazination of terminal alkynes with hydrazides yielding hydrazones 5-14 were successfully catalyzed by a series of gold(I) acyclic aminooxy carbene complexes of the type [{(4-R²-2,6-t-Bu₂-C₆H₂O)(N(R¹)₂)}methylidene]AuCl, where R² = H, R¹ = Me (1b); R² = H, R¹ = Cy (2b); R² = t-Bu, R¹ = Me (3b); R² = t-Bu, R¹ = Cy (4b). The mass spectrometric evidence corroborated the existence of the catalytically active solvent-coordinated [(AAOC)Au(CH₃CN)]SbF₆ (1-4)A species and the acetylene-bound [(AAOC)Au(HC≡CPhMe)]SbF₆ (3B<

SUBMITTER: Singh J 

PROVIDER: S-EPMC10268297 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature