B cell subsets in adult-onset Still's disease: potential candidates for disease pathogenesis and immunophenotyping.

ABSTRACT:

Background

Adult-onset Still's disease (AOSD) is a systemic autoinflammatory disorder of unknown etiology. B cells are critical participants in different rheumatic diseases, and their roles in AOSD are rarely investigated. This study aimed to unveil the B cell subset features in AOSD and provide evidence for B cell-based diagnosis and targeted therapies of AOSD.

Methods

B cell subsets in the peripheral blood of AOSD patients and healthy controls (HCs) were detected by flow cytometry. Firstly, the frequencies of B cell subsets were compared. Then, the correlation analysis was performed to explore the correlation between B cell subsets and clinical manifestations in AOSD. Finally, unbiased hierarchical clustering was performed to divide AOSD patients into three groups with dif

SUBMITTER: Fang X 

PROVIDER: S-EPMC10268358 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature