Bioactivity of human adult stem cells and functional relevance of stem cell-derived extracellular matrix in chondrogenesis.

ABSTRACT:

Background

Autologous chondrocyte implantation (ACI) has been used to treat articular cartilage defects for over two decades. Adult stem cells have been proposed as a solution to inadequate donor cell numbers often encountered in ACI. Multipotent stem/progenitor cells isolated from adipose, bone marrow, and cartilage are the most promising cell therapy candidates. However, different essential growth factors are required to induce these tissue-specific stem cells to initiate chondrogenic differentiation and subsequent deposition of extracellular matrix (ECM) to form cartilage-like tissue. Upon transplantation into cartilage defects in vivo, the levels of growth factors in the host tissue are likely to be inadequate to support chondrogenesis of these cells in situ. The contribution o

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC10268391 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature