GO-Tibia: a masked, randomized control trial evaluating gentamicin versus saline in open tibia fractures.

ABSTRACT:

Background

The rate of open tibia fractures is rapidly increasing across the globe due to a recent rise in road traffic accidents, predominantly in low- and low-middle-income countries. These injuries are orthopedic emergencies associated with infection rates as high as 40% despite the use of systemic antibiotics and surgical debridement. The use of local antibiotics has shown some promise in reducing the burden of infection in these injuries due to increasing local tissue availability; however, no trial has yet been appropriately powered to evaluate for definitive evidence and the majority of current studies have taken place in a high-resource countries where resources and the bio-burden may be different.

Methods

This is a prospective randomized, masked, placebo-controlled

SUBMITTER: Haonga BT 

PROVIDER: S-EPMC10268448 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature