H₂ generated by fermentation in the human gut microbiome influences metabolism and competitive fitness of gut butyrate producers.

ABSTRACT:

Background

Hydrogen gas (H₂) is a common product of carbohydrate fermentation in the human gut microbiome and its accumulation can modulate fermentation. Concentrations of colonic H₂ vary between individuals, raising the possibility that H₂ concentration may be an important factor differentiating individual microbiomes and their metabolites. Butyrate-producing bacteria (butyrogens) in the human gut usually produce some combination of butyrate, lactate, formate, acetate, and H₂ in branched fermentation pathways to manage reducing power generated during the oxidation of glucose to acetate and carbon dioxide. We predicted that a high concentration of intestinal H₂ would favor the production of butyrate, lactate, and formate by the

SUBMITTER: Campbell A 

PROVIDER: S-EPMC10268494 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature