Prematurely delivering mothers show reductions of lachnospiraceae in their gut microbiomes.

ABSTRACT:

Background

Preterm birth is the leading cause of perinatal morbidity and mortality. Despite evidence shows that imbalances in the maternal microbiome associates to the risk of preterm birth, the mechanisms underlying the association between a perturbed microbiota and preterm birth remain poorly understood.

Method

Applying shotgun metagenomic analysis on 80 gut microbiotas of 43 mothers, we analyzed the taxonomic composition and metabolic function in gut microbial communities between preterm and term mothers.

Results

Gut microbiome of mothers delivering prematurely showed decreased alpha diversity and underwent significant reorganization, especially during pregnancy. SFCA-producing microbiomes, particularly species of Lachnospiraceae, Ruminococcaceae, and Eubacteriacea

SUBMITTER: Yang R 

PROVIDER: S-EPMC10268532 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature