Homobimetallic Au(I)-Au(I) and Heterotrimetallic Au(I)-Fe(II)-Au(I) Complexes with Dialkyldithiophosphates and Phosphine Ligands: Structural Characterization, DFT Analysis, and Tyrosinase Inhibitory and Biological Effects.

ABSTRACT: The role of bridging and terminal ligand electronic and steric properties on the structure and antiproliferative activity of two-coordinated gold(I) complexes was investigated on seven novel binuclear and trinuclear gold(I) complexes synthesized by the reaction of either Au₂(dppm)Cl₂, Au₂(dppe)Cl₂, or Au₂(dppf)Cl₂ with potassium diisopropyldithiophosphate, K[(S-OⁱPr)₂], potassium dicyclohexyldithiophosphate, K[(S-OCy)₂], or sodium bis(methimazolyl)borate, Na(S-Mt)₂, which afforded air-stable gold(I) complexes. In 1-7, the gold(I) centers adopt a two-coordinated linear geometry and are structurally similar. However, their structural features and antiproliferativ

SUBMITTER: Neshat A 

PROVIDER: S-EPMC10268621 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature