Dihydropyrazole Derivatives Act as Potent α-Amylase Inhibitors and Free Radical Scavengers: Synthesis, Bioactivity Evaluation, Structure-Activity Relationship, ADMET, and Molecular Docking Studies.

ABSTRACT: Dihydropyrazole (1-22) derivatives were synthesized from already synthesized chalcones. The structures of all of the synthesized compounds were confirmed by elemental analysis and various spectroscopic techniques. Furthermore, the synthesized compounds were screened against α amylase as well as investigated for antioxidant activities. The synthesized compounds demonstrate good to excellent antioxidant activities with IC₅₀ values ranging between 30.03 and 913.58 μM. Among the 22 evaluated compounds, 11 compounds exhibit excellent activity relative to the standard ascorbic acid IC₅₀ = 287.30 μM. Interestingly, all of the evaluated compounds show good to excellent α amylase activity with IC₅₀ values lying in the range between 0.5509 and 810.73 μM as compared t

SUBMITTER: Ali A 

PROVIDER: S-EPMC10268634 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature