OSA and Subsequent Risk of Hospitalization With Pneumonia, Respiratory Infection, and Total Infection: The Atherosclerosis Risk in Communities Study.

ABSTRACT:

Background

OSA has been linked to microaspiration, systemic inflammation, and suboptimal immune function.

Research question

Is OSA prospectively associated with risk of hospitalization for pneumonia, respiratory, and total infections?

Study design and methods

Prospective cohort. Participants in the Atherosclerosis Risk in Communities (ARIC) study (N = 1,586) underwent polysomnography in 1996-1998 and were followed up through 2018 for infection-related hospitalizations. The apnea-hypopnea index (AHI; events/h) was used to categorize participants as having severe OSA (≥ 30), moderate OSA (15-29), mild OSA (5-14), or a normal breathing pattern (< 5). Cox regression was used to calculate hazard ratios (HRs) and 95% CIs.

Results

ARIC participants were on average 62.

SUBMITTER: Lutsey PL 

PROVIDER: S-EPMC10268811 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature