The dynamic response of quorum sensing to density is robust to signal supplementation and individual signal synthase knockouts.

ABSTRACT: Quorum sensing (QS) is a widespread mechanism of environment sensing and behavioural coordination in bacteria. At its core, QS is based on the production, sensing and response to small signalling molecules. Previous work with Pseudomonas aeruginosa shows that QS can be used to achieve quantitative resolution and deliver a dosed response to the bacteria's density environment, implying a sophisticated mechanism of control. To shed light on how the mechanistic signal components contribute to graded responses to density, we assess the impact of genetic (AHL signal synthase deletion) and/or signal supplementation (exogenous AHL addition) perturbations on lasB reaction-norms to changes in density. Our approach condenses data from 2000 timeseries (over 74 000 individual obser

SUBMITTER: Rattray JB 

PROVIDER: S-EPMC10268839 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature