Recent Progress in Research on Mitochondrion-Targeted Antifungal Drugs: a Review.

ABSTRACT: Fungal infections, which commonly occur in immunocompromised patients, can cause high morbidity and mortality. Antifungal agents act by disrupting the cell membrane, inhibiting nucleic acid synthesis and function, or inhibiting β-1,3-glucan synthase. Because the incidences of life-threatening fungal infections and antifungal drug resistance are continuously increasing, there is an urgent need for the development of new antifungal agents with novel mechanisms of action. Recent studies have focused on mitochondrial components as potential therapeutic drug targets, owing to their important roles in fungal viability and pathogenesis. In this review, we discuss novel antifungal drugs targeting mitochondrial components and highlight the unique fungal proteins involved in the electron transport c

SUBMITTER: Qin Y 

PROVIDER: S-EPMC10269089 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature