Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei.

ABSTRACT: Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsusceptibility in isolates from Malaysia.

SUBMITTER: Hall CM 

PROVIDER: S-EPMC10269091 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature