Dataset Information

Insertion of ISPa1635 in ISCR1 Creates a Hybrid Promoter for bla_PER-1 Resulting in Resistance to Novel β-lactam/β-lactamase Inhibitor Combinations and Cefiderocol.

ABSTRACT: Eleven bla_PER-1-positive Pseudomonas aeruginosa clinical isolates showed variable susceptibility to ceftazidime-avibactam (CZA). The genetic contexts of bla_PER-1 were identical (ISCR1-bla_PER-1-gst) except for the ST697 isolate HS204 (ISCR1-ISPa1635-bla_PER-1-gst). The insertion of ISPa1635 in ISCR1 upstream of bla_PER-1 created a hybrid promoter, which elevated the bla_PER-1 transcription level and resulted in increased resistance to CZA, ceftolozane-tazobactam, cefepime-zidebactam, and cefiderocol. Diversity in the promoter activity of bla_PER-1 partially explains the variable susceptibility to CZA in PER-producing isola

SUBMITTER: Wang L

PROVIDER: S-EPMC10269150 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Dataset Information

Insertion of ISPa1635 in ISCR1 Creates a Hybrid Promoter for bla_PER-1 Resulting in Resistance to Novel β-lactam/β-lactamase Inhibitor Combinations and Cefiderocol.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Insertion of ISPa1635 in ISCR1 Creates a Hybrid Promoter for blaPER-1 Resulting in Resistance to Novel β-lactam/β-lactamase Inhibitor Combinations and Cefiderocol.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Insertion of ISPa1635 in ISCR1 Creates a Hybrid Promoter for bla_PER-1 Resulting in Resistance to Novel β-lactam/β-lactamase Inhibitor Combinations and Cefiderocol.