A spatiotemporal computational model of focused ultrasound heat-induced nano-sized drug delivery system in solid tumors.

ABSTRACT: Focused Ultrasound (FUS)-triggered nano-sized drug delivery, as a smart stimuli-responsive system for treating solid tumors, is computationally investigated to enhance localized delivery of drug and treatment efficacy. Integration of thermosensitive liposome (TSL), as a doxorubicin (DOX)-loaded nanocarrier, and FUS, provides a promising drug delivery system. A fully coupled partial differential system of equations, including the Helmholtz equation for FUS propagation, bio-heat transfer, interstitial fluid flow, drug transport in tissue and cellular spaces, and a pharmacodynamic model is first presented for this treatment approach. Equations are then solved by finite element methods to calculate intracellular drug concentration and treatment efficacy. The main objective of this study is to

SUBMITTER: Moradi Kashkooli F 

PROVIDER: S-EPMC10269399 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature