High-Throughput Profiling of Candida auris Isolates Reveals Clade-Specific Metabolic Differences.

ABSTRACT: Candida auris, a multidrug-resistant human fungal pathogen that causes outbreaks of invasive infections, emerged as four distinct geographical clades. Previous studies identified genomic and proteomic differences in nutrient utilization on comparison to Candida albicans, suggesting that certain metabolic features may contribute to C. auris emergence. Since no high-throughput clade-specific metabolic characterization has been described yet, we performed a phenotypic screening of C. auris strains from all 4 clades on 664 nutrients, 120 chemicals, and 24 stressors. We identified common and clade- or strain-specific responses, including the preferred utilization of various dipeptides as nitrogen source and the inability of the clade II isolate AR 0381 to withstand chemical stress. Further anal

SUBMITTER: Brandt P 

PROVIDER: S-EPMC10269459 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature