Role of the NaHCO₃ Transporter MpsABC in the NaHCO₃-β-Lactam-Responsive Phenotype in Methicillin-Resistant Staphylococcus aureus.

ABSTRACT: Methicillin-resistant Staphylococcus aureus (MRSA) infections are an increasing concern due to their intrinsic resistance to most standard-of-care β-lactam antibiotics. Recent studies of clinical isolates have documented a novel phenotype, termed NaHCO₃ responsiveness, in which a substantial proportion of MRSA strains exhibit enhanced susceptibility to β-lactams such as cefazolin and oxacillin in the presence of NaHCO₃. A bicarbonate transporter, MpsAB (membrane potential-generating system), was recently found in S. aureus, where it plays a role in concentrating NaHCO₃ for anaplerotic pathways. Here, we investigated the role of MpsAB in mediating the NaHCO₃ responsiveness phenotype. Radiolabeled NaH¹⁴CO₃

SUBMITTER: Fan SH 

PROVIDER: S-EPMC10269494 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature