Honokiol Inhibits SARS-CoV-2 Replication in Cell Culture at a Post-Entry Step.

ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019, and the resulting pandemic has already caused the death of over 6 million people. There are currently few antivirals approved for treatment of the 2019 coronavirus disease (COVID-19), and more options would be beneficial, not only now but also to increase our preparedness for future coronavirus outbreaks. Honokiol is a small molecule from magnolia trees for which several biological effects have been reported, including anticancer and anti-inflammatory activities. Honokiol has also been shown to inhibit several viruses in cell culture. In this study, we determined that honokiol protected Vero E6 cells from SARS-CoV-2-mediated cytopathic effect, with a 50% effective concentration of 7.8 μM. In viral load reduction

SUBMITTER: Salgado-Benvindo C 

PROVIDER: S-EPMC10269499 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature