Remimazolam versus propofol for procedural sedation: a meta-analysis of randomized controlled trials.

ABSTRACT:

Background

To improve patient tolerability and satisfaction as well as minimize complications, procedural sedation has been widely used. Propofol is the most widely used agent for induction of anesthesia and sedation by anesthesiologists. With a different mechanism compared to propofol, remimazolam is a new short-acting GABA-A receptor agonist. It is an ester-based benzodiazepine. This meta-analysis aims to clarify the efficacy and safety of remimazolam versus propofol for procedure sedation.

Methods

Electronic databases were searched for randomized controlled trials (RCTs) comparing efficacy or safety of remimazolam versus propofol. Meta-analysis were conducted using RStudio with "metafor" package with random-effects model.

Results

A total of twelve RCTs were include

SUBMITTER: Chang Y 

PROVIDER: S-EPMC10269568 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature