Obesity Is Associated with an Impaired Baseline Repertoire of Anti-Influenza Virus Antibodies.

ABSTRACT: Obesity is a risk factor for severe disease and mortality for both influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. While previous studies show that individuals with obesity generate antibody responses following influenza vaccination, infection rates within the obese group were twice as high as those in the healthy-weight group. The repertoire of antibodies raised against influenza viruses following previous vaccinations and/or natural exposures is referred to here as baseline immune history (BIH). To investigate the hypothesis that obesity impacts immune memory to infections and vaccines, we profiled the BIH of obese and healthy-weight adults vaccinated with the 2010-2011 seasonal influenza vaccine in response to conformational and linear antigens. Des

SUBMITTER: Abd Alhadi M 

PROVIDER: S-EPMC10269616 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature