Exploring Molecular Interactions between Human Milk Hormone Insulin and Bifidobacteria.

ABSTRACT: Multiple millennia of human evolution have shaped the chemical composition of breast milk toward an optimal human body fluid for nutrition and protection and for shaping the early gut microbiota of newborns. This biological fluid is composed of water, lipids, simple and complex carbohydrates, proteins, immunoglobulins, and hormones. Potential interactions between hormones present in mother's milk and the microbial community of the newborn are a very fascinating yet unexplored topic. In this context, insulin, in addition to being one of the most prevalent hormones in breast milk, is also involved in a metabolic disease that affects many pregnant women, i.e., gestational diabetes mellitus (GDM). Analysis of 3,620 publicly available metagenomic data sets revealed that the bifidobacterial comm

SUBMITTER: Rizzo SM 

PROVIDER: S-EPMC10269646 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature