comCDE (Competence) Operon Is Regulated by CcpA in Streptococcus pneumoniae D39.

ABSTRACT: Natural transformation plays an important role in the formation of drug-resistant bacteria. Exploring the regulatory mechanism of natural transformation can aid the discovery of new antibacterial targets and reduce the emergence of drug-resistant bacteria. Competence is a prerequisite of natural transformation in Streptococcus pneumoniae, in which comCDE operon is the core regulator of competence. To date, only ComE has been shown to directly regulate comCDE transcription. In this study, a transcriptional regulator, the catabolite control protein A (CcpA), was identified that directly regulated comCDE transcription. We confirmed that CcpA binds to the cis-acting catabolite response elements (cre) in the comCDE promoter region to regulate comCDE tra

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10269683 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature