Meta-Analysis Reveals Compositional and Functional Microbial Changes Associated with Osteoporosis.

ABSTRACT: Over the past decade, the role of the gut microbiota in many disease states has gained a great deal of attention. Mounting evidence from case-control and observational studies has linked changes in the gut microbiota to the pathophysiology of osteoporosis (OP). Nonetheless, the results of these studies contain discrepancies, leaving the literature without a consensus on osteoporosis-associated microbial signatures. Here, we conducted a comprehensive meta-analysis combining and reexamining five publicly available 16S rRNA partial sequence data sets to identify gut bacteria consistently associated with osteoporosis across different cohorts. After adjusting for the batch effect associated with technical variation and heterogeneity of studies, we observed a significant shift in the microbiota

SUBMITTER: Akinsuyi OS 

PROVIDER: S-EPMC10269714 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature