The Small Protein ScrA Influences Staphylococcus aureus Virulence-Related Processes via the SaeRS System.

ABSTRACT: Staphylococcus aureus is a Gram-positive commensal and opportunistic pathogen able to cause diseases ranging from mild skin infections to life-threatening endocarditis and toxic shock syndrome. The ability to cause such an array of diseases is due to the complex S. aureus regulatory network controlling an assortment of virulence factors, including adhesins, hemolysins, proteases, and lipases. This regulatory network is controlled by both protein and RNA elements. We previously identified a novel regulatory protein called ScrA, which, when overexpressed, leads to the increased activity and expression of the SaeRS regulon. In this study, we further explore the role of ScrA and examine the consequences to the bacterial cell of scrA gene disruption. These results demonstrate that scr

SUBMITTER: Wittekind MA 

PROVIDER: S-EPMC10269730 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature