BopN is a Gatekeeper of the Bordetella Type III Secretion System.

ABSTRACT: The classical Bordetella species infect the respiratory tract of mammals. While B. bronchiseptica causes rather chronic respiratory infections in a variety of mammals, the human-adapted species B. pertussis and B. parapertussis_HU cause an acute respiratory disease known as whooping cough or pertussis. The virulence factors include a type III secretion system (T3SS) that translocates effectors BteA and BopN into host cells. However, the regulatory mechanisms underlying the secretion and translocation activity of T3SS in bordetellae are largely unknown. We have solved the crystal structure of BopN of B. pertussis and show that it is similar to the structures of gatekeepers that control access to the T3SS channel from the bacterial cytoplasm. We further found that Bop

SUBMITTER: Navarrete KM 

PROVIDER: S-EPMC10269732 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature