The Local Tumor Microbiome Is Associated with Survival in Late-Stage Colorectal Cancer Patients.

ABSTRACT: The gut microbiome is associated with survival in colorectal cancer. Single organisms have been identified as markers of poor prognosis. However, in situ imaging of tumors demonstrate a polymicrobial tumor-associated community. To understand the role of these polymicrobial communities in survival, we conducted a nested case-control study in late-stage cancer patients undergoing resection for primary adenocarcinoma. The microbiome of paired tumor and adjacent normal tissue samples was profiled using 16S rRNA sequencing. We found a consistent difference in the microbiome between paired tumor and adjacent tissue, despite strong individual microbial identities. Furthermore, a larger difference between normal and tumor tissue was associated with prognosis: patients with shorter survival

SUBMITTER: Debelius JW 

PROVIDER: S-EPMC10269740 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature