Human Anelloviruses: Influence of Demographic Factors, Recombination, and Worldwide Diversity.

ABSTRACT: Anelloviruses represent the major and most diverse component of the healthy human virome, referred to as the anellome. In this study, we determined the anellome of 50 blood donors, forming two sex- and age-matched groups. Anelloviruses were detected in 86% of the donors. The number of detected anelloviruses increased with age and was approximately twice as high in men as in women. A total of 349 complete or nearly complete genomes were classified as belonging to torque teno virus (TTV), torque teno mini virus (TTMV), and torque teno midi virus (TTMDV) anellovirus genera (197, 88, and 64 sequences, respectively). Most donors had intergenus (69.8%) or intragenus (72.1%) coinfections. Despite the limited number of sequences, intradonor recombination analysis showed 6 intragenus recombination

SUBMITTER: Cebria-Mendoza M 

PROVIDER: S-EPMC10269794 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature