Characterization of Temperate LPS-Binding Bordetella avium Phages That Lack Superinfection Immunity.

ABSTRACT: Bordetella avium causes a highly infectious upper respiratory tract disease in turkeys and other poultry with high economic losses. Considering the antimicrobial resistance crisis, bacteriophages (phages) may be an alternative approach for treating bacterial infections such as bordetellosis. Here, we describe seven B. avium phages, isolated from drinking water and feces from chicken and turkey farms. They showed strong bacteriolytic activity with a broad host range and used lipopolysaccharides (LPS) as a host receptor for their adsorption. All phages are myoviruses based on their structure observed by transmission electron microscopy. Genome sequence analyses revealed genome assembly sizes ranging from 39,087 to 43,144 bp. Their permutated genomes were organized colinearly, with a c

SUBMITTER: Serian D 

PROVIDER: S-EPMC10269795 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature