ISG15 Is Required for the Dissemination of Vaccinia Virus Extracellular Virions.

ABSTRACT: Viruses have developed many different strategies to counteract immune responses, and Vaccinia virus (VACV) is one of a kind in this aspect. To ensure an efficient infection, VACV undergoes a complex morphogenetic process resulting in the production of two types of infective virions: intracellular mature virus (MV) and extracellular enveloped virus (EV), whose spread depends on different dissemination mechanisms. MVs disseminate after cell lysis, whereas EVs are released or propelled in actin tails from living cells. Here, we show that ISG15 participates in the control of VACV dissemination. Infection of Isg15^-/- mouse embryonic fibroblasts with VACV International Health Department-J (IHD-J) strain resulted in decreased EV production, concomitant with reduced induct

SUBMITTER: Becares M 

PROVIDER: S-EPMC10269806 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature