First Report of OXA-181-Producing Enterobacterales Isolates in Latin America.

ABSTRACT: We characterized five carbapenemase-producing Enterobacterales (CPE) isolates from two health care institutions in Lima, Peru. The isolates were identified as Klebsiella pneumoniae (n = 3), Citrobacter portucalensis (n = 1), and Escherichia coli (n = 1). All were identified as bla_OXA-48-like gene carriers using conventional PCR. Whole-genome sequencing found the presence of the bla_OXA-181 gene as the only carbapenemase gene in all isolates. Genes associated with resistance to aminoglycosides, quinolones, amphenicols, fosfomycins, macrolides, tetracyclines, sulfonamides, and trimethoprim were also found. The plasmid incompatibility group IncX3 was identified in all genomes in a truncated Tn6361 transposon flanked by ΔIS<

SUBMITTER: Cuicapuza D 

PROVIDER: S-EPMC10269823 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature