K₂CO₃-promoted synthesis of amides from 1-aryl-2,2,2-trifluoroethanones and amines under mild conditions.

ABSTRACT: A base-promoted amidation of 1-aryl-2,2,2-trifluoroethanones with amines via Haller-Bauer reaction has been developed. In this reaction, the direct transformation of 1-aryl-2,2,2-trifluoroethanones into amides via C(O)-C bond cleavage occurs without the use of any stoichiometric chemical oxidants or transition-metal catalysts. A series of primary and secondary amines are shown to be compatible with this transformation, and several pharmaceutical molecules were synthesized.

SUBMITTER: Zhong P 

PROVIDER: S-EPMC10269829 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature