Epigenetic-Based Regulation of Transcriptome in Escherichia coli Adaptive Antibiotic Resistance.

ABSTRACT: Adaptive antibiotic resistance is a transient metabolic adaptation of bacteria limiting their sensitivity to low, progressively increased, concentrations of antibiotics. Unlike innate and acquired resistance, adaptive resistance is dependent on the presence of antibiotics, and it disappears when the triggering factor is removed. Low concentrations of antibiotics are largely diffused in natural environments, in the food industry or in certain body compartments of humans when used therapeutically, or in animals when used for growth promotion. However, molecular mechanisms underlying this phenomenon are still poorly characterized. Here, we present experiments suggesting that epigenetic modifications, triggered by low concentrations of ampicillin, gentamicin, and ciprofloxacin, may modulate th

SUBMITTER: D'Aquila P 

PROVIDER: S-EPMC10269836 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature