Air pollution is associated with faster cognitive decline in Alzheimer's disease.

ABSTRACT:

Objective

Although chronic exposure to air pollution is associated with an increased risk of dementia in normal elderlies, the effect of chronic exposure to air pollution on the rates of cognitive decline in Alzheimer's disease (AD) has not been elucidated.

Methods

In this longitudinal study, a total of 269 patients with mild cognitive impairment or early dementia due to AD with the evidence of brain β-amyloid deposition were followed-up for a mean period of 4 years. Five-year normalized hourly cumulative exposure value of each air pollutant, such as carbon monoxide (CO), nitrogen dioxide (NO₂ ), sulfur dioxide (SO₂ ), and particulate matter (PM_2.5 and PM₁₀ ), was computed based on nationwide air pollution database. The effects of

SUBMITTER: Lee YG 

PROVIDER: S-EPMC10270255 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature