Multimodal investigation of melanopsin retinal ganglion cells in Alzheimer's disease.

ABSTRACT:

Objective

In Alzheimer's disease (AD), the presence of circadian dysfunction is well-known and may occur early in the disease course. The melanopsin retinal ganglion cell (mRGC) system may play a relevant role in contributing to circadian dysfunction. In this study, we aimed at evaluating, through a multimodal approach, the mRGC system in AD at an early stage of disease.

Methods

We included 29 mild-moderate AD (70.9 ± 11 years) and 26 (70.5 ± 8 years) control subjects. We performed an extensive neurophtalmological evaluation including optical coherence tomography with ganglion cell layer segmentation, actigraphic evaluation of the rest-activity rhythm, chromatic pupillometry analyzed with a new data-fitting approach, and brain functional MRI combined with light stimuli asses

SUBMITTER: La Morgia C 

PROVIDER: S-EPMC10270274 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature