Clinical profile of autoimmune nodopathy with anti-neurofascin 186 antibody.

ABSTRACT:

Objective

Nodal/paranodal autoantibodies identified a group of peripheral neuropathies independent from chronic inflammatory demyelinating polyneuropathy (CIDP). However, nodopathy with antibody against neurofascin 186 (NF186) was rarely reported. We presented a cohort of patients with anti-NF186 antibody and described the clinical profile of them.

Methods

In this retrospective study, 195 patients diagnosed with CIDP and immune mediated idiopathic neuropathies were enrolled. Cell-based assay was used to screen anti-NF186 and anti-NF155 antibodies in serum samples. Teased-fiber immunofluorescence were used as a confirmatory assay. Clinical data of seropositive patients were collected and analyzed.

Results

Among the patients with anti-NF186 antibody, seven patients (58.

SUBMITTER: Liu B 

PROVIDER: S-EPMC10270277 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature