A gut bacterial signature in blood and liver tissue characterizes cirrhosis and hepatocellular carcinoma.

ABSTRACT:

Background

HCC is the leading cause of cancer in chronic liver disease. A growing body of experimental mouse models supports the notion that gut-resident and liver-resident microbes control hepatic immune responses and, thereby, crucially contribute to liver tumorigenesis. However, a comprehensive characterization of the intestinal microbiome in fueling the transition from chronic liver disease to HCC in humans is currently missing.

Methods

Here, we profiled the fecal, blood, and liver tissue microbiome of patients with HCC by 16S rRNA sequencing and compared profiles to nonmalignant cirrhotic and noncirrhotic NAFLD patients.

Results

We report a distinct bacterial profile, defined from 16S rRNA gene sequences, with reduced α-and β-diversity in the feces of patients wi

SUBMITTER: Effenberger M 

PROVIDER: S-EPMC10270494 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature