Evidencing leprosy neuronal inflammation by 18-Fluoro-deoxy-glucose.

ABSTRACT:

Background

Leprosy is caused by multiple interactions between Mycobacterium leprae (M. leprae) and the host's peripheral nerve cells. M. leprae primarily invades Schwann cells, causing nerve damage and consequent development of disabilities. Despite its long history, the pathophysiological mechanisms of nerve damage in the lepromatous pole of leprosy remain poorly understood. This study used the findings of 18F-FDG PET/CT on the peripheral nerves of eight lepromatous patients to evaluate the degree of glucose uptake by peripheral nerves and compared them with clinical, electrophysiological, and histopathological evaluations.

Methods

Eight patients with lepromatous leprosy were included in this study. Six patients were evaluated up to three months after leprosy diagnosis usin

SUBMITTER: Penna PS 

PROVIDER: S-EPMC10270593 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature