A systematic review of non-coding RNA genes with differential expression profiles associated with autism spectrum disorders.

ABSTRACT:

Aims

To identify differential expression of shorter non-coding RNA (ncRNA) genes associated with autism spectrum disorders (ASD).

Background

ncRNA are functional molecules that derive from non-translated DNA sequence. The HUGO Gene Nomenclature Committee (HGNC) have approved ncRNA gene classes with alignment to the reference human genome. One subset is microRNA (miRNA), which are highly conserved, short RNA molecules that regulate gene expression by direct post-transcriptional repression of messenger RNA. Several miRNA genes are implicated in the development and regulation of the nervous system. Expression of miRNA genes in ASD cohorts have been examined by multiple research groups. Other shorter classes of ncRNA have been examined less. A comprehensive systematic review exa

SUBMITTER: Stott J 

PROVIDER: S-EPMC10270643 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature