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Maternal Breast Milk Secretor Phenotype Does Not Affect Infant Susceptibility to Rotavirus Diarrhea.


ABSTRACT: Breast milk secretor status is associated with antibody seroconversion to oral rotavirus vaccination. Here, we were unable to detect a similar impact on risk of infant rotavirus diarrhea or vaccine efficacy through 2 years of life, underscoring limitations of immunogenicity assessment alone in evaluation of oral rotavirus vaccine response.

SUBMITTER: Williams FB 

PROVIDER: S-EPMC10270652 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Maternal Breast Milk Secretor Phenotype Does Not Affect Infant Susceptibility to Rotavirus Diarrhea.

Williams Frank B FB   Kader Md Abdul MA   Dickson Dorothy M DM   Colgate E Ross ER   Alam Masud M   Haque Rashidul R   Petri William A WA   Kirkpatrick Beth D BD   Lee Benjamin B  

Open forum infectious diseases 20230607 6


Breast milk secretor status is associated with antibody seroconversion to oral rotavirus vaccination. Here, we were unable to detect a similar impact on risk of infant rotavirus diarrhea or vaccine efficacy through 2 years of life, underscoring limitations of immunogenicity assessment alone in evaluation of oral rotavirus vaccine response. ...[more]

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